Poster at ECCMID 2007:
K. Skovbo Jensen and N. Frimodt-Møller

Comparison of oral dosage regimens for pivampicillin by Monte Carlo PK/PD simulation

Summary:

While compartmental models employed in a Monte Carlo simulation scheme are frequently used to study PK/PD aspects of antibiotics given intravenously, only few modeling studies of that kind seem to have been reported for drugs when taken as oral doses. In the present study, we tested the ability of a compartmental model to predict concentration-time profiles in serum after PO uptake of pivampicillin. The fitted model was then used to find optimal dosage regimens for pivampicillin with respect to treatment of bacterial upper-respiratory tract infections.

The simulations indicate that for streptococcal infections (MIC≤0.063 mg/L), the total daily dose can be reduced to less than 40% if the intake is distributed on three instead of two occations per day.

Additional search terms: Streptococcus pneumoniae, S. pyogenes, population PK model parameters, probability of target attainment (PTA), oral dosage